Molecular Properties, Bioactivity Scores, and Toxicity Predictions of the Phytoconstituents Present in Bauhinia Acuminata

Neelima Kudumula; Noota Divya; Nagamalla Sravika; Saketha Priya; Pachava Anusha; Mudavath Sai Jyotsna

doi:10.18535/ijsrm/v9i07.mp02

Abstract

ABSTRACT:

To develop the herbal drug with the least side effects, there are superior opportunities to discover the medicinal and other biological properties. Natural products serve as sources of beneficial chemical molecules. For this study, Bauhinia acuminata an important medicinal plant of the Indian subcontinent that belongs to the family Fabaceae was chosen. The plant is well known for its precautionary action in tuberculosis. It has been established to possess some pharmacological activities such as membranes Stabilizing activity¹, antibacterial², anti-nociceptive³, thrombolytic activity⁴, antioxidant⁵, anthelmintic⁶, anti-diarrheal⁷, Hepato-protective ⁸.

Phytoconstituents present in Bauhinia acuminata obey Lipinski's rule (MiLog P <5) except Kaempferol-3-glucoside indicated their drug-likeness property. Rhoeagenine, 9, 12, 15-octadecatrienoic acid, and 9, 12-octadecadienoic acid are the phytoconstituents showing all types of binding with all types of receptors binding except Kinase inhibitor activity.

Rhoeagenine, Alpha humulene, 9, 12, 15-octadecatrienoic acid, 9, 12-octadecadienoic acid, Alpha muurolol, Beta-sitosterol, Kaempferol-3-glucoside are the phytoconstituents that are free from any type of toxicity. The accurate prediction scores can be used as monographs by researchers and scientists for the development of potential Semisynthetic and synthetic drugs for multifarious usage.

Keywords

Bauhinia acuminataMolinspiration softwareOsiris softwareToxicity profilePhytoconstituentsBioactivity score. I

References

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[refR-2] In vitro Antioxidant, Cytotoxic and Membrane Stabilizing Activities of Bauhinia acuminata L. | Mohammad Firoz Khan - Academia.eduGoogle Scholar ↗

[refR-3] Phansri K, Sarnthima R, Thammasirirak S, Boonchalee P, Khammuang S (2011). Antibacterial activity of Bauhiniaacuminata L. seed protein extract with low hemolytic activity against human erythrocytes. Chiang Mai Journal of Science, 38(2):242–251.Google Scholar ↗

[refR-4] https://www.thaiscience.info/Journals/Article/CMJS/10905420.pdfGoogle Scholar ↗

[refR-5] Padgaonkar AV, Suryavanshi SV, Londhe VY, Kulkarni YA (2018). Acute toxicity study and anti-nociceptive activity of Bauhinia acuminata Linn leaf extracts in experimental animal models. Biomedicine and Pharmacotherapy, 2(7):158–168.Google Scholar ↗

[refR-6] Acute toxicity study and anti-nociceptive activity of Bauhinia acuminata Linn. leaf extracts in experimental animal models - PubMed (nih.gov)Google Scholar ↗

[refR-7] Islam M, Fahad M, Hossain M, Mamun M, Ferdous M (2014). In-vitro Cytotoxic and thrombolytic activity of methanolic extraction of Bauhinia acuminata leaves. Pharmaceutical and Bioscience, 2(2):4–6.Google Scholar ↗

[refR-8] (PDF) In-vitro Cytotoxic and Thrombolytic Activity of Methanolic Extract of Bauhinia acuminata Leaves | Md.Reyad ferdous - Academia.eduGoogle Scholar ↗

[refR-9] Khan MF, Shilpi RI, Rashid R, Rashid M (2014). In vitro antioxidant, cytotoxic and membrane stabilizing activities of Bauhinia acuminata L. Bangladesh Pharmaceutical Journal, 17(1):99–101.Google Scholar ↗

[refR-10] Prabhu R, Razali N, Dhandapani N, Nagaraj P, Muthaiyan P, Joseph JR (2018). In Vitro Anthelmintic Study of Bauhinia Acuminata Linn. Leaf Extracts against the Indo American Journal of Pharmaceutical Sciences, 05(06):5082–5089.Google Scholar ↗

[refR-11] www.stuartxchange.org/Bambang.htmlGoogle Scholar ↗

[refR-12] Islam MN, Fahad AB (2014). In-vivo Antidiarrheal and In-vitro Antimicrobial Activities of the Leaf Extracts of Bauhinia acuminata. American Journal of Research Communication, 2(7):158–168.Google Scholar ↗

[refR-13] Islam_Vol27.pdf (usa-journals.com)Google Scholar ↗

[refR-14] Ravali P, Challa PK, Soundarya V (2015). Hepatoprotective activity of ethanolic Bauhinia acuminata. L Extract against CCI4-Induced liver damage in rat. Pharma Research Library, 8:8-12.Google Scholar ↗

[refR-15] IJMPR3719.pdf (pharmaresearchlibrary.com)Google Scholar ↗

[refR-16] Yi F (2016). In silico profiling for secondary metabolites from Lepidium meyenii(maca) by the pharmacophore and ligand-shape-based joint approach. Chin Med, 11(1):42.Google Scholar ↗

[refR-17] In silico profiling for secondary metabolites from Lepidium meyenii (maca) by the pharmacophore and ligand-shape-based joint approach (biomedcentral.com)Google Scholar ↗

[refR-18] Dongray R, Chanchal D, Chaudhary S (2016). Phytochemical and Pharmacological Properties of Bauhinia Acuminata. World Journal of Pharmaceutical Research, 5(01):531–546.Google Scholar ↗

[refR-19] https://www.semanticscholar.org/paper/PHYTOCHEMICAL-AND-PHARMACOLOGICAL-PROPERTIES-OF-Dongray- Irchhaiya/14a2c30c7640523f61778fc5c47b81f80756e1fcGoogle Scholar ↗

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